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Miltefosine Hydrate

产品编号:3114145
产品类别:两性离子去污剂
纯度规格:≥98% (HPLC)
包装规格:10MG,50MG
产品价格
产品编号包装单位价格(元)国内现货国外库存购物车
311414510MG594
311414550MG2160

Miltefosine Hydrate

Choline hexadecyl phosphate

HePC

Hexadecyl phosphocholine

Impavido

Miltex

结构式
基本信息
经验分子式(希尔表示法)
C21H46NO4P · xH2O
分子量
407.57 (anhydrous basis)
Application【应用】
Miltefosine, a bioactive alkylphospholipd, may be used to study its pharmacokinetics, metabolism, safety, efficacy and delivery formulation as a potential therapeutic for use in cancer treatments such as cutaneous lymphoma, cutaneous metastatic melanoma, squamous cell carcinoma, and cutaneous metastases of breast cancer. It may also be used to study its mechanism of action and value as an anti-leishmaniasis (antiprotozoan) drug. Miltefosine may be used to study its effect on cell signaling pathways that involve processes such as p38 MAPK pathway activation and differential down regulation of Akt signaling.
Biochem/physiol Actions【生物化学/生理学作用】
Miltefosine induces apoptosis of triple-negative (TN) breast cancer cells by activation of p38 MAPK pathway and differential down regulation of Akt signaling. Miltefosine is an effective anti-tumor treatment of cutaneous lymphoma, cutaneous metastatic melanoma, squamous cell carcinoma, and cutaneous metastases of breast cancer. It also shows remarkable effectiveness against visceral leishmaniasis. Both the anti-tumor and the antiprotozoal activities appear to be exerted first by insertion of the molecule into the plasma membrane where it interferes with phospholipid metabolism.
产品性质
description【描述】
zwitterionic
Assay【含量】
≥98% (HPLC)
form【形态】
powder
storage condition【储存条件】
desiccated
color【颜色】
white to off-white
solubility【溶解度】
H2O: >2 mg/mL
storage temp.【存储温度】
2-8℃
安全信息
符号
 
信号词
Warning
危害声明
H302-H317
警示性声明
P280
危害码 (欧洲)
Xn
风险声明 (欧洲)
22-43
安全声明 (欧洲)
36/37
RIDADR【欧洲内陆运输危险品】
NONH for all modes of transport
WGK德国【德国水污染分类】
3
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