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Anti-XPO4 antibody, Mouse monoclonal
| 产品编号： | 3154530 |
| 规格： | clone XP-12, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-XPO4 antibody, Mouse monoclonal
Monoclonal Anti-XPO4 antibody produced in mouse
Anti-Exportin 4
Anti-KIAA1721
Monoclonal Anti-Exp4
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-XPO4 (mouse IgG1 isotype) is derived from the hybridoma XP-12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide. Exportin 4 (XPO4) belongs to the karyopherins protein family. It is conserved amongst higher eukaryotes but, lacks obvious orthologues in yeast. |
| Immunogen【免疫原】 | a peptide corresponding to a sequence at the C-terminus of human XPO4. |
| Application【应用】 | Monoclonal Anti-XPO4 antibody produced in mouse has been used in immunoblotting and immunofluorescence. |
| Biochem/physiol Actions【生化/生理作用】 | Exportin 4 (XPO4) facilitates the nuclear export of eIF-5A (eukaryotic translation initiation factor 5A). In addition, it also mediates transport Sox proteins, as well as regulates Smad signaling. These functions of XPO4 suggests it to be a candidate tumor suppressor gene. Indeed, its involvement in the progression of human hepatocellular carcinomas (HCC) has been demonstrated, implicating this protein as a potential target for treatment of HCC. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | XP-12, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~130 kDa |
| species reactivity | monkey, human, chicken, canine, bovine, hamster |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: suitable western blot: 1.0-2.0 μg/mL using extracts of HeLa cells |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | Q9C0E2 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... XPO4(64328) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
